Explains the complex nature of body fat and why both too much and too little are deleterious to health. Describes how genes, eating behavior, macronutrients, physiology, microorganisms, and the environment interact to produce obesity. Outlines how the food industry’s production of hyperpalatable foods fuels sweet, fat, and salt addiction and the obesity epidemic. Identifies the most effective diets that could produce long-lasting results in weight loss. Explains strategies for maintaining successful weight loss, managing food cravings, and treating emotional overeating. Identifies the relative effectiveness of diet, exercise, medications, and surgery in maintaining weight loss. Describes how the information in this course can be utilized to improve patient care and patient outcomes. Describes, for this course, the implications for dentistry, mental health, nursing, and other healthcare professions.